short conserved motif in alyref directs cap

REF proteins mediate the export of spliced and

The REF family of evolutionarily conserved heterogeneous ribonucleoprotein (hnRNP)-like proteins consists of one central RNP-type RNA binding domain flanked by Arg-Gly-rich regions of variable length. Members of this protein family bind directly to RNA and the mRNA export factor TAP/Mex67p, and it has been suggested that they facilitate the recruitment of TAP/Mex67p to cellular mRNPs.

The Interaction between Cap-binding Complex and

RNA export factor (REF) is a component of the exon junction complex (EJC) that is deposited on mRNA in a splicing-dependent manner, and targets spliced mRNA for export. In this study, analysis of the RNA-binding protein complexes revealed that REF associates with -globin mRNA at the region other than the EJC deposition site. Comparison between RNA polymerase II and T7 transcription and ALYREF Aly/REF export factor - Gene - GTR - NCBIApr 18, 2021 · A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. Gromadzka AM, Steckelberg AL, Singh KK, Hofmann K, Gehring NHGromadzka AM, et al . Nucleic Acids Res, 2016 Mar 18.

Co-transcriptional Loading of RNA Export Factors Shapes

A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. Nucleic Acids Res. 2016; 44 :2348-2361 Crossref Co-transcriptional Loading of RNA Export Factors Shapes Jul 25, 2019 · A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs Nucleic Acids Res. , 44 ( 2016 ) , pp. 2348 - 2361 CrossRef View Record in Scopus Google Scholar

Curriculum Vitae - The mRNPs Laboratory

A short conserved motif in ALYREF directs cap-and EJC-dependent assembly of export complexes on spliced mRNAs. Nucleic Acid Research . 2016; 44 (5), 2348-2361. Singh, K.K. , Wachsmuth L., Kulozik, DDX39B - Spliceosome RNA helicase DDX39B - Homo Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC)

Estrogen receptor (ER) indirectly induces transcription

Nov 14, 2019 · In an genome wide identification of high-affinity estrogen receptor binding sites in human and mouse cells, no direct ER binding to OAT1 promoter was seen within 70,000 identified motifs (Bourdeau et al., 2004). Those data led us to the new hypothesis that ligand-activated ER indirectly induces OAT1 promoter by initiation of other proteins Luzp4 defines a new mRNA export pathway in cancer cells A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate Overlapping motifs on the herpes viral proteins ICP27 and ORF57 mediate interactions with the mRNA export adaptors ALYREF and UIF

Nuclear export of RNA:Different sizes, shapes and

Mar 01, 2018 · A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs Nucleic Acids Res. , 44 ( 5 ) ( 2016 ) , pp. 2348 - 2361 CrossRef View Record in Scopus Google Scholar PUBLICATIONS STECKELBERG LABA short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. Nucleic Acids Res. 2016 Mar 18;44(5):2348-61. Steckelberg AL, Altmueller J, Dieterich C, Gehring NH. CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.

Structure of the human core transcription-export complex

Nov 16, 2020 · ALYREF contains two UAP56-binding motifs (UBMs) at its N- and C-terminus that can separately bind UAP56 (Hautbergue et al., (2016) A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on The dynamic RNA modification 5methylcytosine and its Oct 11, 2018 · Moreover, knock-down of ALYREF in HeLa cells resulted in increased nuclear retention of m 5 C-modified mRNA which could be rescued by eion of wild-type ALYREF but not of a mutant version that was unable to bind m 5 C. In contrast, non-m 5 C bearing mRNA showed no nuclear export defects upon ALYREF knockdown (Yang et al., 2017).

The functional complexity of the RNA-binding protein Yra1

Jul 10, 2019 · Gromadzka AM, Steckelberg AL, Singh KK, Hofmann K, Gehring NH (2016) A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. Nucleic Acids Res 44(5):23482361. CAS PubMed PubMed Central Google Scholar The m 6 A-methylase complex recruits TREX and regulates Sep 14, 2018 · Gromadzka, A. M., Steckelberg, A. L., Singh, K. K., Hofmann, K. & Gehring, N. H. A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on

anti-Homo sapiens (Human) ALYREF Antibody raised in

anti-ALYREF Antibody reacting with Rabbit and identified with WB, ELISA. Quality is guaranteed. exon junction complex:structural insights into a faithful During splicing, the exon junction complex (EJC) is deposited upstream of exon-exon boundaries. The EJC and its peripheral bound proteins play an essential role in mediating mRNA export, translation and turnover. However, the exact sequence of EJC assembly and the involved factors during splicing remain elusive. Recently published structures of the human C* spliceosome clarified the position

ncRNA Free Full-Text RNA Surveillance by the Nuclear

The nuclear RNA exosome is an essential and versatile machinery that regulates maturation and degradation of a huge plethora of RNA species. The past two decades have witnessed remarkable progress in understanding the whole picture of its RNA substrates and the structural basis of its functions. In addition to the exosome itself, recent studies focusing on associated co-factors have been A short conserved motif in ALYREF directs cap- and EJC Apr 01, 2016 · A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs. (PMID:26773052 PMCID:PMC4797287) PMID:26773052 PMCID:PMC4797287